Gellan gum fluid gels for topical administration of diclofenac
نویسندگان
چکیده
منابع مشابه
Development of mucoadhesive sprayable gellan gum fluid gels.
The nasal mucosa provides a potentially good route for local and systemic drug delivery. However, the protective feature of the nasal cavity make intranasal delivery challenging. The application of mucoadhesive polymers in nasal drug delivery systems enhances the retention of the dosage form in the nasal cavity. Several groups have investigated using low acyl gellan as a drug delivery vehicle b...
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Salt is a requirement material for human body but should be regulated as its excessive consumption might lead to heart disease and blood pressure. Processed foods due to high salt content might include about three quarter of the daily salt intake therefore many people consume more than their recommended allowances. Processed foods contain added salt for varieties of reasons namely to enhance th...
متن کاملEvaluation of gellan gum fluid gels as modified release oral liquids.
Oral liquids are often preferred for drug administration to patients for whom swallowing is difficult, however, formulating modified release versions can be challenging. A potential route to achieve modified release in oral liquids is by using fluid (sheared) gels formed by introducing a shear field during gelation in gel-forming biopolymers. These fluid gels can act as pourable viscoelastic fl...
متن کاملEffects of Potassium Gum Gels Chloride and SodiumChlorideon the Thermal Properties of Gellan
(DSC) for gellan gum gels without and with potassium chloride and sodium chloride were analyzed. The gelling and melting temperatures shifted to higher temperatures with increasing gellan and salt concentration in the concentration range of gellan from O.3 to 2.0% (wlw). The exothermic and endothermic enthalpy increased with increasing ge]lan and salt concentrations. Cooling DSC curves showed o...
متن کاملEnhanced gelation properties of purified gellan gum.
Gellan gum is a hydrogel-forming polysaccharide when combined with monovalent or divalent cations such as sodium, magnesium, potassium or calcium. Commercially, gellan gums are sold with trace amounts of these cations, which have been proven to affect the gelation and mechanical properties of the resultant hydrogels. A new method based on impedance analysis for determining the gel transition te...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutics
سال: 2016
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2016.10.048